靶向药|简单改变靶向药用法，效果居然好这么多？！( 二 )
特别高兴看到塞瑞替尼优秀的最新数据，参与的科学家们功不可没，肯定都很有成就感 。
随着越来越多靶向新药的出现，未来ALK融合突变肺癌患者很多都可能活到5年，甚至7年以上 。对于他们而言，癌症可能会变成一种慢性病，这对增强患者治疗信念、提高生存质量都是一种里程碑式的转变 。相信会有更多的好消息，让“钻石”更加闪亮 。
致敬生命！
*本文旨在科普癌症新药背后的科学，不是药物宣传资料，更不是治疗方案推荐 。如需获得疾病治疗方案指导，请前往正规医院就诊 。
参考文献：
[1] ASCEND-8: A Randomized Phase 1 Study ofCeritinib, 450 Mg or 600 Mg, Taken With a Low-Fat Meal Versus 750 Mg in FastedState in Patients With Anaplastic Lymphoma Kinase (ALK)-Rearranged MetastaticNon-Small Cell Lung Cancer (NSCLC). J Thorac Oncol. 2017 Sep;12(9):1357-1367.
[2]I1171 Missense Mutation (ParticularlyI1171N) Is a Common Resistance Mutation in ALK-positive NSCLC Patients Who HaveProgressive Disease While on Alectinib and Is Sensitive to Ceritinib. LungCancer. 2015 May;88(2):231-4.
[3]Targeting ALK: Precision Medicine Takes onDrug Resistance. Cancer Discovery. 2017 Feb;7(2):137-155.
[4]Comparative Efficacy of Ceritinib andCrizotinib as Initial ALK-Targeted Therapies in Previously Treated AdvancedNSCLC: An Adjusted Comparison with External Controls. J Thorac Oncol. 2016Sep;11(9):1550-7.
[5]First-line ceritinib versus platinum-basedchemotherapy in advanced ALK-rearranged non-small-cell lung cancer (ASCEND-4):a randomised, open-label, phase 3 study. Lancet. 2017 Mar 4;389(10072):917-929.
[6]Ceritinib in ALK-rearranged non-small-celllung cancer. N Engl J Med. 2014 Mar 27;370(13):1189-97
[7]Multicenter Phase II Study of Whole-Bodyand Intracranial Activity With Ceritinib in Patients With ALK-RearrangedNon-Small-Cell Lung Cancer Previously Treated With Chemotherapy and Crizotinib:Results From ASCEND-2. J Clin Oncol. 2016 Aug 20;34(24):2866-73.
[8]First-line ceritinib versus platinum-basedchemotherapy in advanced ALK-rearranged non-small-cell lung cancer (ASCEND-4):a randomised, open-label, phase 3 study. Lancet. 2017 Mar 4;389(10072):917-929.
[9]Ceritinib versus chemotherapy in patientswith ALK-rearranged non-small-cell lung cancer previously given chemotherapyand crizotinib (ASCEND-5): a randomised, controlled, open-label, phase 3 trial.Lancet Oncol. 2017 Jul;18(7):874-886.
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